My caution over what I put in my body lost me that which I consider most valuable, even as my career progressed. The risks currently appear to be minor for my healthy, young, male demographic whether I had a more severe side effect or caught the virus. At the same time, it was much more likely to have an immediate side effect from the vaccine in my demographic than for others. This did not consider the long-term impact of that change in transcription could have. This is the worst with Moderna. I also weighed the fact that it was a guaranteed risk if I got an experimental vaccine that would teach my body to produce an endothelial disrupting spike protein, and a chance if I caught the virus. I did catch it twice. The first felt like a bad flu with some additional symptoms of brain fog and exhaustion for a few days. The second time I mostly had a sore throat. Since they were six months apart, I assume that while the more broad and durable natural immunity lasts longer than the vaccination, it is not perpetual. Further, there appears to be no correlation between catching the virus itself and the incidence of myocarditis or pericarditis.
With that it means that an argument I had been making for the benefit of natural immunity over a mass vaccination drive isn’t as solid as it had been. While there is no correlation between vaccine uptake and covid-19 spread, and the delta virus has made this coronavirus endemic, natural immunity is not a guaranteed path to herd immunity with a single infection. Due to the repeated injection of mRNA vaccines leading to an IgG4 response, I do not believe that those vaccines would do the same even if one boosts with the same solution more than ten times. I do wonder if a response to a more traditional protein as attenuated vaccines like Novavax could rekindle that broad and durable natural immunity, especially if the system previously had exposure to the virus itself. If that were the case, then the potential for spread effecting others could be reduced more effectively than seems to be the case from the mRNA vaccines. I believe that because of the specificity of the alpha spike protein production in the mRNA vaccines the immunity was not only therapeutic in nature, but also was the reason behind the narrow immunity which required an updated dose for a mutated strain, as well as repeated boosters.
One of my concerns beyond the spike protein itself was the use of polyethylene-glycol as an adjuvant. The nanolipids seemed to cross the blood brain barrier and got stored in areas like the spleen and and liver. This is potentially carcinogenic. Looking at Europe though, cancers appear to be going down, with some exceptions. So that does not appear to be true in that highly vaccinated population. Also, considering the sheer magnitude of carcinogenic substances that are omnipresent in modern western society, it would be difficult to pinpoint which was the greatest contributing factor should an increase appear in the mortality statistics. However, polyethylene glycol does seem to be strongly correlated with anaphylaxis.
Within the Novavax vaccine there is a different adjuvant. The Matrix-M adjuvant is from a Chilean saponin, which appear to have some health benefits for cholesterol and others. At the same time, there were severe reactions which were unlikely, but still more probable than my death from the virus. These include .01% myocarditis or pericarditis, .03% chance of cardiac failure, and .03% chance of acute cholecystitis. Primarily it was just redness and pain. As a result, I think my preference for this shot is based on a little bit of superstition I have which is that natural medicines are superior to experimental artificial substances. After all, if one cares for the body with exercise, vitamin D (especially with vitamin K), takes zinc, and does any of a variety of other things one reduces the risk of severe illness from many sources, not just covid-19.